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Hepatic Encephalopathy Summary

Description: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Also Known As: Encephalopathy, Hepatocerebral; Encephalopathy, Portal-Systemic; Encephalopathy, Portosystemic; Fulminant Hepatic Failure with Cerebral Edema; Hepatic Coma Show All >>

Networked: 3480 relevant articles (224 outcomes, 392 trials/studies) for this Disease

Key Drugs and Agents for Hepatic Encephalopathy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Lactulose (Duphalac) : 35 outcomes 36 studies in 243 results : FDA 31 Generic
  2. rifaximin (L 105) : 26 outcomes 25 studies in 126 results : FDA 2
  3. Ammonia : 20 outcomes 36 studies in 548 results : IBA
  4. Flumazenil (Romazicon) : 11 outcomes 15 studies in 64 results : FDA 10 Generic
  5. Bilirubin : 11 outcomes 5 studies in 142 results : IBA
  6. ornithylaspartate : 10 outcomes 7 studies in 38 results : IBA
  7. lactitol : 7 outcomes 15 studies in 49 results : IBA
  8. Zinc : 6 outcomes 5 studies in 30 results : IBA
  9. Sorbitol (Yal) : 6 outcomes 4 studies in 16 results : FDA 6
  10. Branched-Chain Amino Acids : 5 outcomes 16 studies in 87 results : IBA
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Diseases Related to Hepatic Encephalopathy

  1. Fibrosis (Cirrhosis)
  2. Liver Cirrhosis (Hepatic Cirrhosis)
  3. Hyperammonemia
  4. Acute Liver Failure (Fulminant Hepatic Failure)
  5. Ascites
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Key Therapies for Hepatic Encephalopathy

Efficacy Chart >>
  1. Surgical Portasystemic Shunt (Portosystemic Shunt) : 7 outcomes 20 studies in 156 results
  2. Liver Transplantation : 6 outcomes 11 studies in 153 results
  3. Transplantation (Transplant Recipients) : 5 outcomes 2 studies in 44 results
  4. Aftercare (After-Treatment) : 5 outcomes in 19 results
  5. Surgical Portacaval Shunt (Portacaval Anastomosis) : 4 outcomes 8 studies in 99 results
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