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Hemochromatosis (Bronze Diabetes) Summary

Description: A disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary. Full development of the disease in women is restricted by menstruation, pregnancy, and lower dietary intake of iron. Acquired hemochromatosis may be the result of blood transfusions, excessive dietary iron, or secondary to other disease. Idiopathic or genetic hemochromatosis is an autosomal recessive disorder of metabolism associated with a gene tightly linked to the A locus of the HLA complex on chromosome 6. (From Dorland, 27th ed)

Also Known As: Bronze Diabetes; Hemochromatoses; Diabetes, Bronze

Networked: 2564 relevant articles (48 outcomes, 243 trials/studies) for this Disease

Key Drugs and Agents for Hemochromatosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Iron : 31 outcomes 137 studies in 1550 results : IBA
  2. Ferritins (Ferritin) : 5 outcomes 52 studies in 256 results : IBA
  3. Transferrin (beta 2 Transferrin) : 2 outcomes 38 studies in 251 results : IBA
  4. hepcidin : 2 outcomes 13 studies in 208 results : IBA
  5. Deferoxamine (Desferal) : 2 outcomes 5 studies in 60 results : FDA 5 Generic
  6. Messenger RNA (mRNA) : 2 outcomes 4 studies in 22 results : IBA
  7. Glucose (Dextrose) : 2 outcomes 2 studies in 21 results : FDA 175 Generic
  8. Ribavirin (Virazole) : 2 outcomes in 4 results : FDA 16 Generic
  9. metal transporting protein 1 (ferroportin) : 1 outcome 5 studies in 84 results : IBA
  10. Heme (Haem) : 1 outcome 3 studies in 13 results : IBA
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Diseases Related to Hemochromatosis

  1. Iron Overload
  2. Anemia
  3. Fibrosis (Cirrhosis)
  4. End Stage Liver Disease
  5. Sideroblastic Anemia
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Key Therapies for Hemochromatosis

Efficacy Chart >>
  1. Chelation Therapy (Therapy, Chelation) : 3 outcomes 1 study in 11 results
  2. Liver Transplantation : 2 outcomes 1 study in 37 results
  3. Renal Dialysis (Hemodialysis) : 2 outcomes 1 study in 18 results
  4. Blood Transfusion (Blood Transfusions) : 1 outcome 3 studies in 35 results
  5. Heart Transplantation (Grafting, Heart) : 1 outcome in 2 results
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