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Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) Summary

Description: An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)

Also Known As: Encephalomyelitis, Autoimmune Experimental; Allergic Encephalomyelitis; Experimental Allergic Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Allergic Encephalomyelitis, Experimental Show All >>

Networked: 5042 relevant articles (387 outcomes, 589 trials/studies) for this Disease

Key Drugs and Agents for Experimental Autoimmune Encephalomyelitis

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Drugs and Important Biological Agents (IBA) related to treatments:
  1. oligodendrocyte-myelin glycoprotein : 18 outcomes 50 studies in 387 results : IBA
  2. copolymer 1 (glatiramer acetate) : 17 outcomes 5 studies in 79 results : FDA 1
  3. Antigens : 13 outcomes 34 studies in 392 results : IBA
  4. Cytokines : 10 outcomes 16 studies in 158 results : IBA
  5. fingolimod (FTY720) : 9 outcomes 7 studies in 38 results : FDA 1
  6. Estrogens (Estrogen) : 9 outcomes 6 studies in 51 results : FDA 1
  7. Interleukin-10 (Interleukin 10) : 7 outcomes 5 studies in 76 results : IBA
  8. Ligands : 6 outcomes 13 studies in 44 results : IBA
  9. DNA (Deoxyribonucleic Acid) : 6 outcomes 5 studies in 47 results : IBA
  10. PPAR gamma : 6 outcomes 4 studies in 18 results : IBA
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Diseases Related to Experimental Autoimmune Encephalomyelitis

  1. Multiple Sclerosis
  2. Inflammation
  3. Autoimmune Diseases (Autoimmune Disease)
  4. Demyelinating Diseases (Demyelinating Disease)
  5. Experimental Arthritis
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Key Therapies for Experimental Autoimmune Encephalomyelitis

Efficacy Chart >>
  1. Transplantation (Transplant Recipients) : 6 outcomes 7 studies in 26 results
  2. Oral Administration : 6 outcomes 3 studies in 67 results
  3. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 3 outcomes 2 studies in 17 results
  4. Intravenous Injections : 3 outcomes in 8 results
  5. Injections : 2 outcomes 3 studies in 32 results
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