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Cystic Fibrosis (Mucoviscidosis) Summary

Description: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Also Known As: Mucoviscidosis; Fibrocystic Disease of Pancreas; Pancreatic Cystic Fibrosis; Pulmonary Cystic Fibrosis; Cystic Fibrosis, Pancreatic Show All >>

Networked: 12969 relevant articles (552 outcomes, 1327 trials/studies) for this Disease

Key Drugs and Agents for Cystic Fibrosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Tobramycin (Nebcin) : 44 outcomes 63 studies in 343 results : FDA 44 Generic
  2. Anti-Bacterial Agents (Antibiotics) : 39 outcomes 61 studies in 550 results : IBA
  3. human DNASE1 protein (dornase alfa) : 26 outcomes 44 studies in 197 results : FDA 2
  4. Azithromycin (Zithromax) : 20 outcomes 18 studies in 104 results : FDA 39 Generic
  5. Ceftazidime (Fortum) : 17 outcomes 17 studies in 111 results : FDA 14 Generic
  6. DNA (Deoxyribonucleic Acid) : 16 outcomes 51 studies in 452 results : IBA
  7. Ciprofloxacin (Cipro) : 13 outcomes 22 studies in 137 results : FDA 60 Generic
  8. Diffuse panbronchiolitis : 12 outcomes 5 studies in 57 results : IBA
  9. Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR) : 10 outcomes 34 studies in 1207 results : IBA
  10. Mannitol (Osmitrol) : 9 outcomes 13 studies in 47 results : FDA 28 Generic
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Diseases Related to Cystic Fibrosis

  1. Infection
  2. Lung Diseases (Lung Disease)
  3. Bronchiectasis
  4. Asthma (Bronchial Asthma)
  5. Chronic Obstructive Pulmonary Disease (COPD)
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Key Therapies for Cystic Fibrosis

Efficacy Chart >>
  1. Lung Transplantation : 25 outcomes 31 studies in 554 results
  2. Microspheres (Microsphere) : 6 outcomes 3 studies in 23 results
  3. Transplants (Transplant) : 5 outcomes 25 studies in 284 results
  4. Drug Therapy (Chemotherapy) : 5 outcomes 3 studies in 75 results
  5. Nebulizers and Vaporizers (Inhaler) : 4 outcomes 15 studies in 82 results
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