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Crush Syndrome Summary

Description: Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.

Also Known As: Crush Syndromes; Syndrome, Crush; Syndromes, Crush

Networked: 157 relevant articles (7 outcomes, 16 trials/studies) for this Disease

Key Drugs and Agents for Crush Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Creatine Kinase (Creatine Phosphokinase) : 1 outcome in 5 results : IBA
  2. Proline (L-Proline) : 1 outcome in 3 results : FDA 18
  3. Mannitol (Osmitrol) : 1 outcome in 2 results : FDA 28 Generic
  4. Nerve Growth Factor (NGF) : 1 outcome in 1 result : IBA
  5. Dalteparin (Dalteparin Sodium) : 1 outcome in 1 result : FDA 2
  6. Peptides : 1 outcome in 1 result : IBA
  7. Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight) : 1 outcome in 1 result : IBA
  8. Ethylene Oxide (Oxirane) : 1 outcome in 1 result : IBA
  9. Myoglobin : 2 studies in 9 results : IBA
  10. Antioxidants : 1 study in 3 results : IBA
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Diseases Related to Crush Syndrome

  1. Spinal Cord Injuries (Spinal Cord Injury)
  2. Malnutrition
  3. Traumatic Shock
  4. Inflammation
  5. Acute Kidney Injury (Acute Renal Failure)
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Key Therapies for Crush Syndrome

Efficacy Chart >>
  1. Renal Replacement Therapy (Therapies, Renal Replacement) : 1 outcome in 7 results
  2. Fluid Therapy (Oral Rehydration Therapy) : 1 outcome in 4 results
  3. Blood Transfusion (Blood Transfusions) : 1 outcome in 2 results
  4. Decompression : 2 studies in 9 results
  5. Renal Dialysis (Hemodialysis) : 1 study in 8 results
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