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Chloroguanide (Proguanil) Summary

Description: A biguanide compound which has little antimalarial activity until metabolized in the body to the active antimalarial agent cycloguanil. The usefulness of proguanil is limited by the rapid development of drug resistance by the malarial parasite. The hydrochloride is used for the casual prophylaxis of falciparum malaria, to suppress other forms of malaria, and to reduce transmission of infection (From Martindale, The Extra Pharmacopoeia, 30th ed, p405)

Also Known As: Proguanil; Paludrine; Astra Brand of Chloroguanide Hydrochloride; AstraZeneca Brand of Chloroguanide Hydrochloride; Bigumal Show All >>

Networked: 279 relevant articles (40 outcomes, 34 trials/studies) for this Drug

Key Diseases for which Chloroguanide is Relevant

  1. Malaria : 20 outcomes 13 studies in 145 results
  2. Falciparum Malaria (Plasmodium falciparum Malaria) : 16 outcomes 12 studies in 70 results
  3. Infection : 4 outcomes 3 studies in 29 results
  4. Vivax Malaria : 1 outcome 2 studies in 9 results
  5. Theileriasis : 1 outcome in 1 result
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Drugs Related to Chloroguanide

  1. Chloroquine (Aralen)
  2. Atovaquone (Mepron)
  3. Mefloquine (Lariam)
  4. cycloguanil
  5. Dapsone
  6. sulfadoxine-pyrimethamine (Fansidar)
  7. Chloroguanide (Proguanil)
  8. Pyrimethamine (Daraprim)
  9. Antimalarials (Antimalarial Agents)
  10. malarone
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Therapies Related to Chloroguanide

  1. Chemoprevention
  2. Protective Clothing
  3. Drug Therapy (Chemotherapy)
  4. Mosquito Nets
  5. Directly Observed Therapy
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