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Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) Summary

Description: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)

Also Known As: Peroneal Muscular Atrophy; Roussy Levy Syndrome; Syndrome, Roussy-Levy; Charcot-Marie Disease; Charcot-Marie-Tooth Disease, Type I Show All >>

Networked: 546 relevant articles (7 outcomes, 38 trials/studies) for this Disease

Key Drugs and Agents for Charcot-Marie-Tooth Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. tebufenozide (Mimic) : 1 outcome in 4 results : IBA
  2. Tea : 1 outcome in 1 result : IBA
  3. Prednisolone (Predate) : 1 outcome in 1 result : FDA 55 Generic
  4. Curcumin : 1 outcome in 1 result : IBA
  5. pioglitazone (Actos) : 1 outcome in 1 result : FDA 9
  6. resveratrol : 1 outcome in 1 result : IBA
  7. gallocatechol (epigallocatechin) : 1 outcome in 1 result : IBA
  8. modafinil (armodafinil) : 1 outcome in 1 result : FDA 10
  9. connexin 32 : 3 studies in 56 results : IBA
  10. Dynamin II : 2 studies in 8 results : IBA
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Diseases Related to Charcot-Marie-Tooth Disease

  1. Myotonic Dystrophy (Dystrophia Myotonica)
  2. Spinal Muscular Atrophy (Progressive Muscular Atrophy)
  3. Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
  4. Friedreich Ataxia (Friedreich's Ataxia)
  5. Neuromuscular Diseases (Neuromuscular Disease)
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Key Therapies for Charcot-Marie-Tooth Disease

Efficacy Chart >>
  1. Resistance Training : 2 outcomes 2 studies in 7 results
  2. Orthotic Devices (Orthosis) : 3 studies in 6 results
  3. Osteotomy : 1 study in 8 results
  4. Arthrodesis : 1 study in 6 results
  5. Denervation : 1 study in 5 results
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