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Cerebral Palsy (Spastic Diplegia) Summary

Description: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)

Also Known As: Spastic Diplegia; Cerebral Palsy, Congenital; Cerebral Palsy, Spastic; Athetoid Cerebral Palsy; Dyskinetic Cerebral Palsy Show All >>

Networked: 3299 relevant articles (226 outcomes, 590 trials/studies) for this Disease

Key Drugs and Agents for Cerebral Palsy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Botulinum Toxins (Botulinum Toxin) : 43 outcomes 76 studies in 322 results : IBA
  2. Type A Botulinum Toxins (Botulinum A Toxin) : 18 outcomes 40 studies in 161 results : FDA 2
  3. Baclofen : 18 outcomes 31 studies in 152 results : FDA 31 Generic
  4. Magnesium Sulfate (Sulfate, Magnesium) : 4 outcomes 24 studies in 68 results : FDA 7 Generic
  5. pamidronate (APD) : 4 outcomes 3 studies in 9 results : FDA 16 Generic
  6. Trihexyphenidyl (Artane) : 3 outcomes 4 studies in 11 results : FDA 16 Generic
  7. Glycopyrrolate (Glycopyrronium Bromide) : 3 outcomes 4 studies in 7 results : FDA 21 Generic
  8. Oxygen : 2 outcomes 11 studies in 74 results : IBA
  9. abobotulinumtoxinA : 2 outcomes 6 studies in 12 results : FDA 2
  10. Growth Hormone (Somatotropin) : 2 outcomes 1 study in 13 results : IBA
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Diseases Related to Cerebral Palsy

  1. Muscle Spasticity (Spastic)
  2. Sialorrhea
  3. Congenital Abnormalities (Deformity)
  4. Dystonia (Limb Dystonia)
  5. Pain (Aches)
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Key Therapies for Cerebral Palsy

Efficacy Chart >>
  1. Injections : 16 outcomes 33 studies in 128 results
  2. Rhizotomy : 15 outcomes 29 studies in 219 results
  3. Orthotic Devices (Orthosis) : 11 outcomes 31 studies in 120 results
  4. Osteotomy : 8 outcomes 25 studies in 134 results
  5. Resistance Training : 6 outcomes 19 studies in 51 results
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