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Cataplexy Summary

Description: A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)

Also Known As: Cataleptic Attacks; Attack, Cataleptic; Attacks, Cataleptic; Cataleptic Attack; Syndrome, Henneberg Show All >>

Networked: 604 relevant articles (53 outcomes, 69 trials/studies) for this Disease

Key Drugs and Agents for Cataplexy

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Sodium Oxybate (gamma Hydroxybutyrate) : 22 outcomes 13 studies in 92 results : FDA 1
  2. modafinil (armodafinil) : 6 outcomes 3 studies in 37 results : FDA 10
  3. Clomipramine (Anafranil) : 6 outcomes 1 study in 17 results : FDA 9 Generic
  4. orexins (orexin) : 3 outcomes 23 studies in 254 results : IBA
  5. Imipramine (Janimine) : 3 outcomes 1 study in 10 results : FDA 46 Generic
  6. Intravenous Immunoglobulins (IVIG) : 3 outcomes 1 study in 7 results : FDA 1
  7. Tricyclic Antidepressive Agents (Tricyclic Antidepressants) : 2 outcomes 2 studies in 16 results : IBA
  8. Fluoxetine (Prozac) : 2 outcomes 1 study in 11 results : FDA 51 Generic
  9. venlafaxine (Effexor) : 2 outcomes in 8 results : FDA 18 Generic
  10. Antidepressive Agents (Antidepressants) : 1 outcome 7 studies in 39 results : IBA
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Diseases Related to Cataplexy

  1. Narcolepsy
  2. Disorders of Excessive Somnolence (Hypersomnia)
  3. Sleep Paralysis
  4. Hallucinations (Hallucination)
  5. Seizures (Seizure)
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Key Therapies for Cataplexy

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 1 outcome in 8 results
  2. Immunotherapy : 1 outcome in 3 results
  3. Oral Administration : 1 outcome in 3 results
  4. Cesarean Section (Caesarean Section) : 2 results
  5. Off-Label Use : 1 result
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