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Anencephaly (Aprosencephaly) Summary

Description: A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247)

Also Known As: Aprosencephaly; Absence of Brain, Congenital; Anencephalia; Anencephalus; Congenital Absence of Brain Show All >>

Networked: 440 relevant articles (4 outcomes, 24 trials/studies) for this Disease

Key Drugs and Agents for Anencephaly

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Folic Acid (Vitamin M) : 3 outcomes 9 studies in 73 results : FDA 50 Generic
  2. Lipoproteins (Lipoprotein) : 1 outcome in 2 results : IBA
  3. Apolipoprotein A-I (Apolipoprotein A1) : 1 outcome in 1 result : IBA
  4. HDL Lipoproteins : 1 outcome in 1 result : IBA
  5. Dexamethasone (Maxidex) : 1 outcome in 1 result : FDA 77 Generic
  6. Apoproteins : 1 outcome in 1 result : IBA
  7. alpha-Fetoproteins (AFP) : 2 studies in 48 results : IBA
  8. Vitamins : 2 studies in 13 results : IBA
  9. Estriol (Epiestriol) : 1 study in 7 results : IBA
  10. MicroRNAs (MicroRNA) : 1 study in 2 results : IBA
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Diseases Related to Anencephaly

  1. Spinal Dysraphism (Spina Bifida)
  2. Neural Tube Defects (Exencephaly)
  3. Diaphragmatic Hernia
  4. Hypercholesterolemia
  5. Spina Bifida Cystica (Spina Bifida Aperta)
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Key Therapies for Anencephaly

Efficacy Chart >>
  1. Transplantation (Transplant Recipients) : 1 study in 5 results
  2. Induced Labor : 1 study in 1 result
  3. Induced Abortion (Induced Abortions) : 6 results
  4. Organ Transplantation : 4 results
  5. Prenatal Care : 4 results
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