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Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Summary

Description: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

Also Known As: Lou Gehrig's Disease; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Lou Gehrig Disease; ALS (Amyotrophic Lateral Sclerosis); Amyotrophic Lateral Sclerosis With Dementia Show All >>

Networked: 5913 relevant articles (140 outcomes, 584 trials/studies) for this Disease

Key Drugs and Agents for Amyotrophic Lateral Sclerosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Riluzole : 14 outcomes 34 studies in 174 results : FDA 4 Generic
  2. Lithium : 7 outcomes 13 studies in 30 results : IBA
  3. Antioxidants : 6 outcomes 2 studies in 18 results : IBA
  4. Glutamic Acid (Glutamate) : 4 outcomes 15 studies in 216 results : FDA 7
  5. Insulin-Like Growth Factor I (IGF-1) : 4 outcomes 11 studies in 32 results : IBA
  6. Creatine : 4 outcomes 7 studies in 31 results : IBA
  7. superoxide dismutase 1 : 3 outcomes 24 studies in 260 results : IBA
  8. Biological Markers (Surrogate Marker) : 3 outcomes 11 studies in 100 results : IBA
  9. Proteins (Proteins, Gene) : 3 outcomes 9 studies in 231 results : IBA
  10. Nerve Growth Factors (Neurotrophins) : 3 outcomes 4 studies in 42 results : IBA
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Diseases Related to Amyotrophic Lateral Sclerosis

  1. Neurodegenerative Diseases (Neurodegenerative Disease)
  2. Parkinson Disease (Parkinson's Disease)
  3. Alzheimer Disease (Alzheimer's Disease)
  4. Stroke (Strokes)
  5. Huntington Disease (Huntington's Disease)
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Key Therapies for Amyotrophic Lateral Sclerosis

Efficacy Chart >>
  1. Tracheostomy : 4 outcomes 12 studies in 44 results
  2. Ketogenic Diet : 3 outcomes 1 study in 4 results
  3. Transplantation (Transplant Recipients) : 2 outcomes 5 studies in 29 results
  4. Positive-Pressure Respiration (PEEP) : 2 outcomes 3 studies in 25 results
  5. Electrodes (Electrode) : 2 outcomes 2 studies in 13 results
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