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alpha-MSH Summary

Description: A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.

Also Known As: (Des-Acetyl)-alpha-MSH; (Desacetyl)alpha-MSH; ACTH (1-13); ACTH (1-13)NH2; ACTH(1-13) Show All >>

Networked: 855 relevant articles (44 outcomes, 112 trials/studies) for this Bio-Agent

Key Diseases for which alpha-MSH is Relevant

  1. Melanoma (Melanoma, Malignant) : 11 outcomes 42 studies in 230 results
  2. Neoplasms (Cancer) : 5 outcomes 7 studies in 52 results
  3. Inflammation : 3 outcomes 5 studies in 98 results
  4. Ischemia : 3 outcomes in 19 results
  5. Reperfusion Injury : 3 outcomes in 9 results
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Drugs Related to alpha-MSH

  1. alpha-MSH
  2. Peptides
  3. Adrenocorticotropic Hormone (ACTH)
  4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  5. Hydrocortisone (Cortisol)
  6. NF-kappa B (NF-kB)
  7. Bleomycin (Blenoxane)
  8. Melanocyte-Stimulating Hormones (MSH)
  9. Melanins (Melanin)
  10. beta-Endorphin (Endorphin, beta)
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Therapies Related to alpha-MSH

  1. Induced Hypothermia
  2. Intravenous Injections
  3. Intraventricular Infusions
  4. Ligation
  5. Subcutaneous Injections
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