Search Login Register

mitochondrial permeability transition pore Summary

Description: Mitochondrial permeability transition pores is a function describing leaky mitochondria without known structure; one model proposed is being an aggregation of misfolded membrane proteins (possibly including cyclophilin D from the matrix, the adenine nucleotide translocator from the inner membrane, the voltage-dependent anion channel from the outer membrane and others including creatine kinase in the intermembrane space, hexokinase at the outer surface of the outer membrane, the peripheral benzodiazepine receptor, and Bax protein [He, FEBS Let 512:1 2002 PMID: 11852041].

Also Known As: cyclosporin A-SPTP; cyclosporin A-sensitive pereability transition pore; mPTP protein; mitochondrial megachannel (MMC); permeability transition pore, mitochondrial

Networked: 395 relevant articles (13 outcomes, 36 trials/studies) for this Bio-Agent

Key Diseases for which mitochondrial permeability transition pore is Relevant

  1. Ischemia : 6 outcomes 9 studies in 79 results
  2. Reperfusion Injury : 3 outcomes 7 studies in 99 results
  3. Myocardial Ischemia (Ischemic Heart Diseases) : 2 outcomes in 17 results
  4. Neoplasms (Cancer) : 1 outcome 2 studies in 17 results
  5. Hypothermia : 1 outcome 1 study in 3 results
Show All >>

Drugs Related to mitochondrial permeability transition pore

  1. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
  2. Adenosine Triphosphate (ATP)
  3. Atractyloside
  4. 5-hydroxydecanoic acid
  5. Cyclosporine (Ciclosporin)
  6. Phosphotransferases (Kinase)
  7. Potassium Channels (Potassium Channel)
  8. Leptin
  9. cyclophilin D
  10. Calcineurin
Show All >>

Therapies Related to mitochondrial permeability transition pore

  1. Ischemic Postconditioning
  2. Induced Heart Arrest (Cardioplegia)
  3. Vagus Nerve Stimulation
  4. Resuscitation
  5. Intraperitoneal Injections

CureHunter Inc. provides medical information and specifically does NOT provide medical advice.
© Copyright 2003-2016 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.